Chronic Pain Protocols

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Integrative supplement protocols to support pain management — curated by Dr. Kendra using evidence-based research and professional-grade ingredients.

All supplements available through Dr. Kendra's Fullscript Dispensary with a 10% patient discount.

General Chronic Pain Support

Chronic pain is more than just "something that hurts" — it involves real changes in how your nervous system processes signals. Inflammation, nerve sensitization, and nutrient deficiencies all play a role. These supplements target the root causes of persistent pain rather than just masking symptoms.

  • Curcumin 500 w/Bioperine (Pure Encapsulations / Integrative Therapeutics, ~$35) — One of the most researched natural anti-inflammatories. It blocks multiple inflammation pathways (COX-2, NF-kB). The Bioperine (black pepper extract) increases absorption by up to 2,000%.
  • ProOmega 2000 (Nordic Naturals, ~$49) — High-dose omega-3s help resolve inflammation. Your body converts EPA and DHA into "resolvins" and "protectins" that actively shut down the inflammatory process.
  • Magnesium Glycinate (Pure Encapsulations, ~$25) — A natural muscle relaxant that plays a key role in nerve signal transmission. The glycinate form also has a calming effect that helps with sleep disruption from chronic pain.
  • PEA (Palmitoylethanolamide) (Designs for Health, ~$40) — A naturally occurring fatty acid that works through your endocannabinoid system (like CBD) but without psychoactive effects. Particularly effective for nerve pain and central sensitization.
  • Vitamin D3 5,000 IU (Pure Encapsulations, ~$15) — Deficiency is remarkably common in chronic pain patients. Correcting it alone can sometimes meaningfully reduce pain levels.

Estimated monthly cost: ~$164 (before your 10% Fullscript discount)

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Osteoarthritis Support

Osteoarthritis happens when cartilage cushioning your joints wears down over time. While you can't fully rebuild lost cartilage, you can slow the process, reduce inflammation, and support the structures you still have.

  • Glucosamine Chondroitin w/MSM (Integrative Therapeutics, ~$35) — The building blocks your body uses to maintain and repair cartilage. Together, they can slow cartilage breakdown and reduce joint stiffness.
  • Curcumin 500 w/Bioperine (~$35) — Studies show curcumin can be as effective as ibuprofen for osteoarthritis pain, with fewer side effects on your stomach and kidneys.
  • ProOmega 2000 (Nordic Naturals, ~$49) — Omega-3s reduce inflammatory enzymes that actively break down cartilage and help lubricate joints from the inside out.
  • Collagen Peptides (Designs for Health / Thorne, ~$30) — Type II collagen provides joints with the specific protein they need for cartilage maintenance.
  • Boswellia (Integrative Therapeutics, ~$25) — Contains boswellic acids that block 5-LOX, a powerful driver of joint inflammation. Works through a different pathway than curcumin.

Estimated monthly cost: ~$174 (before your 10% Fullscript discount)

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Chronic Low Back Pain Support

Low back pain is one of the most common reasons people seek medical care, driven by muscle tension, inflammation, and sometimes disc or nerve involvement.

  • Curcumin 500 w/Bioperine (Integrative Therapeutics, ~$35) — Targets inflammation around spinal joints, discs, and nerve roots.
  • Magnesium Glycinate (Pure Encapsulations, ~$25) — Helps chronically tight back muscles relax properly after contraction.
  • ProOmega 2000 (Nordic Naturals, ~$49) — Reduces systemic inflammation contributing to disc degeneration and nerve irritation.
  • Devil's Claw (Nature's Way, ~$15) — An African plant with solid clinical evidence for low back pain. Multiple European studies show it can reduce need for conventional pain medication.
  • Vitamin D3 5,000 IU (Pure Encapsulations, ~$15) — Supports bone density in vertebrae, muscle strength in core stabilizers, and reduces inflammatory pain signals.

Estimated monthly cost: ~$139 (before your 10% Fullscript discount)

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Neuropathy Support

Neuropathy — tingling, numbness, burning, or shooting pain in hands and feet — happens when nerves are damaged, often by diabetes, chemotherapy, or other causes. These supplements focus on protecting nerve cells and supporting their repair.

  • Alpha Lipoic Acid 600mg (Pure Encapsulations, ~$61) — One of the most well-studied supplements for neuropathy. It protects nerve cells from oxidative damage and improves blood flow to tiny blood vessels feeding your nerves. Used as a prescription treatment in Germany for decades.
  • B-Complex Plus (Pure Encapsulations, ~$20) — B12 and B6 maintain the myelin sheath — the protective coating around your nerves. Deficiency can actually cause neuropathy on its own.
  • Acetyl-L-Carnitine (Pure Encapsulations, ~$35) — Helps nerve cells produce energy and promotes nerve fiber regeneration. Can cross the blood-brain barrier to directly support nerve cell repair.
  • Magnesium Glycinate (Pure Encapsulations, ~$25) — Supports healthy nerve signal transmission and helps calm overexcited nerve pathways.
  • ProOmega 2000 (Nordic Naturals, ~$49) — Supports nerve cell membrane health. DHA is a major structural component of nerve cell membranes.

Estimated monthly cost: ~$190 (before your 10% Fullscript discount)

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Fibromyalgia Support

Fibromyalgia involves widespread pain, fatigue, and "brain fog" caused by changes in how your central nervous system processes pain signals — essentially, your pain volume is turned up too high.

  • Magnesium Glycinate (Pure Encapsulations, ~$25) — Many fibromyalgia patients have low magnesium. Supplementation reduces pain severity, tender points, and fatigue. The glycinate form also supports sleep quality.
  • CoQ10 (Pure Encapsulations, ~$45) — Research suggests impaired cellular energy production in fibromyalgia. CoQ10 is essential for mitochondria to generate energy. Studies show reduced pain and morning tiredness.
  • Vitamin D3 5,000 IU (Pure Encapsulations, ~$15) — Deficiency is significantly more common in fibromyalgia and associated with increased pain sensitivity.
  • ProOmega 2000 (Nordic Naturals, ~$49) — Reduces neuroinflammation that amplifies pain signals. Also supports brain function to help with "fibro fog."
  • Rhodiola Rosea (Integrative Therapeutics, ~$25) — An adaptogen that helps manage stress and fatigue. Supports healthy cortisol levels and improves energy and mental clarity over 4–8 weeks.

Estimated monthly cost: ~$159 (before your 10% Fullscript discount)

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→ Browse All Pain Support Supplements on Fullscript

Important: These supplements are meant to support — not replace — the care you receive from your doctors, pain specialists, and physical therapists. Always talk to your healthcare provider before starting any new supplement, especially if you take prescription pain medications, blood thinners, or other medications. Do not stop or reduce prescribed medications without medical guidance.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.